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Sanofi pan-tgf-β neutralizing antibody 1d11
Micro-CT Parameters of Midshaft Femoral Cortical Bone for WT, Crtap −/− , and Col1a2 +/p.G610C Mice
Pan Tgf β Neutralizing Antibody 1d11, supplied by Sanofi, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/pan-tgf-β neutralizing antibody 1d11/product/Sanofi
Average 90 stars, based on 1 article reviews
pan-tgf-β neutralizing antibody 1d11 - by Bioz Stars, 2026-03
90/100 stars

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1) Product Images from "Correlations Between Bone Mechanical Properties and Bone Composition Parameters in Mouse Models of Dominant and Recessive Osteogenesis Imperfecta and the Response to Anti-TGF-β Treatment"

Article Title: Correlations Between Bone Mechanical Properties and Bone Composition Parameters in Mouse Models of Dominant and Recessive Osteogenesis Imperfecta and the Response to Anti-TGF-β Treatment

Journal: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

doi: 10.1002/jbmr.2997

Micro-CT Parameters of Midshaft Femoral Cortical Bone for WT, Crtap −/− , and Col1a2 +/p.G610C Mice
Figure Legend Snippet: Micro-CT Parameters of Midshaft Femoral Cortical Bone for WT, Crtap −/− , and Col1a2 +/p.G610C Mice

Techniques Used: Micro-CT

(A) The extrinsic mechanical parameters maximum load, stiffness, post-yield energy, and post-yield displacement of femurs from WT, OI control, and anti-TGF-β-treated (OI anti-TGF-β) mice are shown for the Crtap−/− and Col1a2+/p.G610C models. (B) The intrinsic mechanical parameters ultimate strength, elastic modulus, post-yield toughness, and post-yield strain of femurs of WT, OI control, and OI anti-TGF-β mice are shown for the Crtap−/− and Col1a2+/p.G610C models. *p < 0.05. The mechanical parameters of femurs of Crtap−/− mice are parts of the data set included in an earlier publication(10) and are reproduced here for ease in comparing to the data from the Col1a2+/p.G610C model.
Figure Legend Snippet: (A) The extrinsic mechanical parameters maximum load, stiffness, post-yield energy, and post-yield displacement of femurs from WT, OI control, and anti-TGF-β-treated (OI anti-TGF-β) mice are shown for the Crtap−/− and Col1a2+/p.G610C models. (B) The intrinsic mechanical parameters ultimate strength, elastic modulus, post-yield toughness, and post-yield strain of femurs of WT, OI control, and OI anti-TGF-β mice are shown for the Crtap−/− and Col1a2+/p.G610C models. *p < 0.05. The mechanical parameters of femurs of Crtap−/− mice are parts of the data set included in an earlier publication(10) and are reproduced here for ease in comparing to the data from the Col1a2+/p.G610C model.

Techniques Used:

Bone compositional parameters mineral-to-collagen ratio, carbonate substitution, collagen content, and hydroxyapatite crystallinity determined by Raman spectroscopy of femurs are shown for WT, OI control, and OI anti-TGF-β mice for the Crtap−/− and Col1a2+/p.G610C models. *p < 0.05.
Figure Legend Snippet: Bone compositional parameters mineral-to-collagen ratio, carbonate substitution, collagen content, and hydroxyapatite crystallinity determined by Raman spectroscopy of femurs are shown for WT, OI control, and OI anti-TGF-β mice for the Crtap−/− and Col1a2+/p.G610C models. *p < 0.05.

Techniques Used: Raman Spectroscopy

Pearson Correlation Coefficients Between the Mechanical Properties and the Raman Imaging Data for the Crtap −/− Model
Figure Legend Snippet: Pearson Correlation Coefficients Between the Mechanical Properties and the Raman Imaging Data for the Crtap −/− Model

Techniques Used: Imaging

Pearson Correlation Coefficients Between the Mechanical Properties and the Raman Imaging Data for the Col1a2 +/p.G610C Model
Figure Legend Snippet: Pearson Correlation Coefficients Between the Mechanical Properties and the Raman Imaging Data for the Col1a2 +/p.G610C Model

Techniques Used: Imaging



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Micro-CT Parameters of Midshaft Femoral Cortical Bone for WT, Crtap −/− , and Col1a2 +/p.G610C Mice

Journal: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Article Title: Correlations Between Bone Mechanical Properties and Bone Composition Parameters in Mouse Models of Dominant and Recessive Osteogenesis Imperfecta and the Response to Anti-TGF-β Treatment

doi: 10.1002/jbmr.2997

Figure Lengend Snippet: Micro-CT Parameters of Midshaft Femoral Cortical Bone for WT, Crtap −/− , and Col1a2 +/p.G610C Mice

Article Snippet: As described, ( 10 ) 8-week-old female Crtap −/− and Col1a2 +/p.G610C mice were treated for 8 weeks with the pan-TGF-β neutralizing antibody 1D11 (provided by Sanofi Genzyme, Cambridge, MA, USA); control female Crtap −/− , Col1a2 +/p.G610C , and WT mice were treated with a control antibody (13C4) of the same IgG1 isotype that does not inhibit TGF-β.

Techniques: Micro-CT

(A) The extrinsic mechanical parameters maximum load, stiffness, post-yield energy, and post-yield displacement of femurs from WT, OI control, and anti-TGF-β-treated (OI anti-TGF-β) mice are shown for the Crtap−/− and Col1a2+/p.G610C models. (B) The intrinsic mechanical parameters ultimate strength, elastic modulus, post-yield toughness, and post-yield strain of femurs of WT, OI control, and OI anti-TGF-β mice are shown for the Crtap−/− and Col1a2+/p.G610C models. *p < 0.05. The mechanical parameters of femurs of Crtap−/− mice are parts of the data set included in an earlier publication(10) and are reproduced here for ease in comparing to the data from the Col1a2+/p.G610C model.

Journal: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Article Title: Correlations Between Bone Mechanical Properties and Bone Composition Parameters in Mouse Models of Dominant and Recessive Osteogenesis Imperfecta and the Response to Anti-TGF-β Treatment

doi: 10.1002/jbmr.2997

Figure Lengend Snippet: (A) The extrinsic mechanical parameters maximum load, stiffness, post-yield energy, and post-yield displacement of femurs from WT, OI control, and anti-TGF-β-treated (OI anti-TGF-β) mice are shown for the Crtap−/− and Col1a2+/p.G610C models. (B) The intrinsic mechanical parameters ultimate strength, elastic modulus, post-yield toughness, and post-yield strain of femurs of WT, OI control, and OI anti-TGF-β mice are shown for the Crtap−/− and Col1a2+/p.G610C models. *p < 0.05. The mechanical parameters of femurs of Crtap−/− mice are parts of the data set included in an earlier publication(10) and are reproduced here for ease in comparing to the data from the Col1a2+/p.G610C model.

Article Snippet: As described, ( 10 ) 8-week-old female Crtap −/− and Col1a2 +/p.G610C mice were treated for 8 weeks with the pan-TGF-β neutralizing antibody 1D11 (provided by Sanofi Genzyme, Cambridge, MA, USA); control female Crtap −/− , Col1a2 +/p.G610C , and WT mice were treated with a control antibody (13C4) of the same IgG1 isotype that does not inhibit TGF-β.

Techniques:

Bone compositional parameters mineral-to-collagen ratio, carbonate substitution, collagen content, and hydroxyapatite crystallinity determined by Raman spectroscopy of femurs are shown for WT, OI control, and OI anti-TGF-β mice for the Crtap−/− and Col1a2+/p.G610C models. *p < 0.05.

Journal: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Article Title: Correlations Between Bone Mechanical Properties and Bone Composition Parameters in Mouse Models of Dominant and Recessive Osteogenesis Imperfecta and the Response to Anti-TGF-β Treatment

doi: 10.1002/jbmr.2997

Figure Lengend Snippet: Bone compositional parameters mineral-to-collagen ratio, carbonate substitution, collagen content, and hydroxyapatite crystallinity determined by Raman spectroscopy of femurs are shown for WT, OI control, and OI anti-TGF-β mice for the Crtap−/− and Col1a2+/p.G610C models. *p < 0.05.

Article Snippet: As described, ( 10 ) 8-week-old female Crtap −/− and Col1a2 +/p.G610C mice were treated for 8 weeks with the pan-TGF-β neutralizing antibody 1D11 (provided by Sanofi Genzyme, Cambridge, MA, USA); control female Crtap −/− , Col1a2 +/p.G610C , and WT mice were treated with a control antibody (13C4) of the same IgG1 isotype that does not inhibit TGF-β.

Techniques: Raman Spectroscopy

Pearson Correlation Coefficients Between the Mechanical Properties and the Raman Imaging Data for the Crtap −/− Model

Journal: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Article Title: Correlations Between Bone Mechanical Properties and Bone Composition Parameters in Mouse Models of Dominant and Recessive Osteogenesis Imperfecta and the Response to Anti-TGF-β Treatment

doi: 10.1002/jbmr.2997

Figure Lengend Snippet: Pearson Correlation Coefficients Between the Mechanical Properties and the Raman Imaging Data for the Crtap −/− Model

Article Snippet: As described, ( 10 ) 8-week-old female Crtap −/− and Col1a2 +/p.G610C mice were treated for 8 weeks with the pan-TGF-β neutralizing antibody 1D11 (provided by Sanofi Genzyme, Cambridge, MA, USA); control female Crtap −/− , Col1a2 +/p.G610C , and WT mice were treated with a control antibody (13C4) of the same IgG1 isotype that does not inhibit TGF-β.

Techniques: Imaging

Pearson Correlation Coefficients Between the Mechanical Properties and the Raman Imaging Data for the Col1a2 +/p.G610C Model

Journal: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Article Title: Correlations Between Bone Mechanical Properties and Bone Composition Parameters in Mouse Models of Dominant and Recessive Osteogenesis Imperfecta and the Response to Anti-TGF-β Treatment

doi: 10.1002/jbmr.2997

Figure Lengend Snippet: Pearson Correlation Coefficients Between the Mechanical Properties and the Raman Imaging Data for the Col1a2 +/p.G610C Model

Article Snippet: As described, ( 10 ) 8-week-old female Crtap −/− and Col1a2 +/p.G610C mice were treated for 8 weeks with the pan-TGF-β neutralizing antibody 1D11 (provided by Sanofi Genzyme, Cambridge, MA, USA); control female Crtap −/− , Col1a2 +/p.G610C , and WT mice were treated with a control antibody (13C4) of the same IgG1 isotype that does not inhibit TGF-β.

Techniques: Imaging